M. Bryan Dalla Betta, DO; Dasia Esener, MD; William Swanson, MD; Andrew Kaddis, MD; Felipe Aguayo Romero, MD; J. Matthew Fields, MD – Sepsis is a syndrome characterized by infection, widespread inflammation and organ dysfunction affecting millions of people in the United States and across the globe each year. Despite recent improvements in sepsis care, it is still associated with high rates of morbidity and mortality, accounting for nearly 270,000 deaths and treatment costs over $20 billion in the United States annually.
Miguel Romano, MD; Eduardo Viana, MS; José Diogo Martins, MD; Rogério Corga da Silva, MD – Sepsis is defined as a life-threatening organ dysfunction caused by a dysregulated host response to infection with a high mortality rate. Septic shock is a subset of sepsis with manifest circulatory dysfunction (use of vasopressors and persistent elevation of lactic acid) . As stated in literature, in addition to the use of empiric antibiotics and control of the infectious focus, intravenous fluid therapy is an essential intervention to promote hemodynamic stabilization. However, the literature also describes harmful outcomes related to fluid overload.