Zahraa Y. Alqallaf, Ossama S. Maadarani, FRCP; Mohamed E. Elhabibi, MD; Mohamad Abdelfatah, MD; Zouheir I. Bitar, FRCP EDIC EDEC – Point of care ultrasound (POCUS) can make an expedited diagnosis, which might lead to early correct management. POCUS should be used in a systemic and integrated approach to evaluate multiple organs in patients with sepsis and septic shock. We present a rare case of sepsis due to nontyphoidal Salmonella endocarditis with splenic abscess in which a multiorgan POCUS examination led to expedited treatment.